SB-357134 ( SB 357134;SB357134 )

产品货号. M13506 CAS No. 219963-52-7

A potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5.

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥7857	有现货
50MG	￥16038	有现货
100MG	￥20250	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

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生物学信息

产品名称

SB-357134
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5.
产品描述

A potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5, displays 1300-fold selectivity over other 13 5-HT receptor subtypes; inhibits 5-HT-stimulated cAMP accumulation in with pA2 of 7.63, enhances memory and learning following chronic administration in mice.
同义词

SB 357134;SB357134
通路

Endocrinology/Hormones
靶点

5-HT Receptor
受体

5-HT Receptor
研究领域

——
适应症

——

化学信息

CAS Number

219963-52-7
分子量

523.22
分子式

C17H18Br2FN3O3S
纯度

>98% (HPLC)
溶解度

——
SMILES

O=S(C1=CC=C(OC)C(N2CCNCC2)=C1)(NC3=CC(Br)=CC(F)=C3Br)=O
化学全称

N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-(piperazin-1-yl)benzene-1-sulfonamide

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Bromidge SM, et al. Bioorg Med Chem Lett. 2001 Jan 8;11(1):55-8.
2. Stean TO, et al. Pharmacol Biochem Behav. 2002 Apr;71(4):645-54.
3. Marcos B, et al. Eur J Neurosci. 2006 Sep;24(5):1299-306.
4. Rogers DC, et al. Psychopharmacology (Berl). 2001 Nov;158(2):114-9.

计算器

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摩尔计算器

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产品手册

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