Rotigotine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

A non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM); has 10-fold selectivity for the D3 receptor over the D2, D4, and D5 receptors and 100-fold selectivity for the D3 receptor over the D1 receptor.

A non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM); has 10-fold selectivity for the D3 receptor over the D2, D4, and D5 receptors and 100-fold selectivity for the D3 receptor over the D1 receptor; behaves as a full agonist of D1, D2, and D3 with similar potencies (EC50) in functional assay; also demonstrates significant affinity at α-adrenergic (α2B, Ki=27 nM) and serotonin receptors (5-HT1A Ki=30 nM); significantly attenuates MPTP-induced acute cell degeneration in mouse model.Parkinson's Disease Approved

N-0923; SPM 962

GPCR/G Protein

Dopamine Receptor

D2;D3

Neurological Disease

Parkinson Disease

99755-59-6

315.47

C19H25NOS

>98% (HPLC)

10 mM in DMSO

CCCN(CCC1=CC=CS1)C2CCC3=C(C2)C=CC=C3O

1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-, (6S)-

(-20℃)

With Ice Pack

≥ 2 years