BP-897

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BP-897 is the first, potent, selective partial dopamine D3 receptor agonist with Ki of 0.92 nM.

BP-897 is the first, potent, selective partial dopamine D3 receptor agonist with Ki of 0.92 nM; displays 70 times lower affinity for D2 (Ki=61 nM), low affinities for D1 and D4 (Ki= 3 and 0.3 uM) and α1 and α2 adrenergic receptor (Ki=60 and 83 nM), negligible affinities (Ki>1 uM) for muscarinic, histamine and opiate receptors; inhibits cocaine-seeking behaviour that depends upon the presentation of drug-associated cues, without having any intrinsic, primary rewarding effects.Parkinson Disease Phase 2 Discontinued

BP897

GPCR/G Protein

Dopamine Receptor

Dopamine Receptor

Neurological Disease

Parkinson Disease

314776-92-6

417.55

C26H31N3O2

>98% (HPLC)

——

O=C(NCCCCN1CCN(C2=CC=CC=C2OC)CC1)C3=CC=C4C=CC=CC4=C3

N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-2-naphthamide

(-20℃)

With Ice Pack

≥ 2 years