Roflumilast ( B 9302-107; BY 217; BYK 20869; Daxas )

产品货号. M12400 CAS No. 162401-32-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Roflumilast
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor.
产品描述

Roflumilast is a phosphodiesterase-4 (PDE-4) inhibitor. Due to its selective inhibition of the PDE4 isoenzyme in lung cells, roflumilast is indicated for the management of chronic obstrtuctive pulmonary disease (COPD) exacerbations. Treatment with Roflumilast is associated with an increase in psychiatric adverse reactions, including suicide and suicidal attempts.
同义词

B 9302-107; BY 217; BYK 20869; Daxas
通路

Angiogenesis
靶点

PDE
受体

PDE4A1; PDE4A4; PDE4B1; PDE4B2; PDE4C1
研究领域

Inflammation/Immunology
适应症

——

CAS Number

162401-32-3
分子量

403.21
分子式

C17H14Cl2F2N2O3
纯度

>98%(HPLC)
溶解度

Ethanol: 15 mg/mL (37.2 mM); DMSO: 81 mg/mL (200.88 mM)
SMILES

O=C(NC1=C(Cl)C=NC=C1Cl)C2=CC=C(OC(F)F)C(OCC3CC3)=C2
化学全称

3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

1.Barone FC, et al. Pharmacology. 2007 Aug 28;81(1):11-17.

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