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PF‐04447943
CAS No. 1082744-20-4
PF‐04447943 ( PF 04447943;PF04447943;PF-4447943 )
产品货号. M10326 CAS No. 1082744-20-4
A potent, selective, brain penetrant, orally active PDE9A inhibitor with IC50 of 8.3 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥672 | 有现货 |
|
| 10MG | ￥1077 | 有现货 |
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| 25MG | ￥2292 | 有现货 |
|
| 50MG | ￥3669 | 有现货 |
|
| 100MG | ￥5897 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PF‐04447943
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A potent, selective, brain penetrant, orally active PDE9A inhibitor with IC50 of 8.3 nM.
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产品描述A potent, selective, brain penetrant, orally active PDE9A inhibitor with IC50 of 8.3 nM; displays high selectivity versus PDEs1-8 and 10-11 (>150-fold over PDE1C, IC50=1394 nM); significantly increases neurite outgrowth and synapse formation in cultured hippocampal neurons at 30-100 nM; enhances synaptic plasticity and cognitive function in rodents.Alzheimer's Disease Phase 2 Clinical
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同义词PF 04447943;PF04447943;PF-4447943
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通路Angiogenesis
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靶点PDE
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受体PDE
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研究领域Neurological Disease
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适应症Alzheimer Disease
化学信息
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CAS Number1082744-20-4
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分子量395.47
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分子式C20H25N7O2
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 54.6 mg/mL 138.07 mM
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SMILESCC1CN(CC1C2=NC3=C(C=NN3C4CCOCC4)C(=O)N2)CC5=NC=CC=N5
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化学全称6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Hutson PH, et al. Neuropharmacology. 2011 Sep;61(4):665-76.
2. Verhoest PR, et al. J Med Chem. 2012 Nov 8;55(21):9045-54.
3. Schwam EM, et al. Curr Alzheimer Res. 2014;11(5):413-21.
2. Verhoest PR, et al. J Med Chem. 2012 Nov 8;55(21):9045-54.
3. Schwam EM, et al. Curr Alzheimer Res. 2014;11(5):413-21.
产品手册
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