PF-2545920(b)
CAS No. 898562-94-2
PF-2545920(b) ( Mardepodec;MP-10;PF-02545920 )
产品货号. M16463 CAS No. 898562-94-2
A potent and selective PDE10A inhibitor with IC50 of 0.37 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥405 | 有现货 |
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5MG | ¥680 | 有现货 |
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10MG | ¥1239 | 有现货 |
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25MG | ¥2090 | 有现货 |
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50MG | ¥3119 | 有现货 |
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100MG | ¥4666 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称PF-2545920(b)
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述A potent and selective PDE10A inhibitor with IC50 of 0.37 nM.
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产品描述A potent and selective PDE10A inhibitor with IC50 of 0.37 nM; displays >1,000-fold selectivity over the PDEs; antagonizes apomorphine-induced climbing in mice, inhibits conditioned avoidance responding in both rats and mice, and blocks NMDA antagonist-induced deficits in prepulse inhibition of acoustic startle response in rats; dose-dependently increases c-Fos immunopositive nuclei in all regions of neostriatum in the DRd1a-tdTomato mice; improves cortico-basal ganglia function in huntington's disease models; orally bioavailable.Schizophrenia Phase 2 Discontinued
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同义词Mardepodec;MP-10;PF-02545920
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通路Angiogenesis
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靶点PDE
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受体PDE
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研究领域Neurological Disease
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适应症Schizophrenia
化学信息
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CAS Number898562-94-2
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分子量392.45
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分子式C25H20N4O
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 45 mg/mL
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SMILESCN1N=C(C2=CC=C(OCC3=NC4=CC=CC=C4C=C3)C=C2)C(C5=CC=NC=C5)=C1
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化学全称Quinoline, 2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
2. Grauer SM, et al. J Pharmacol Exp Ther. 2009 Nov;331(2):574-90.
3. Beaumont V, et al. Neuron. 2016 Dec 21;92(6):1220-1237.
产品手册
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