021-51111890
购物车（）
sales@molnova.cn
Rigosertib
CAS No. 592542-59-1
Rigosertib ( ON-01910 )
产品货号. M24584 CAS No. 592542-59-1
Rigosertib 是一种选择性、非 ATP 竞争性 PLK1 抑制剂 (IC50: 9 nM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥275 | 有现货 |
|
| 5MG | ￥446 | 有现货 |
|
| 10MG | ￥786 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Rigosertib
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述Rigosertib 是一种选择性、非 ATP 竞争性 PLK1 抑制剂 (IC50: 9 nM)。
-
产品描述Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which induces apoptosis by inhibition of the PI3 kinase/Akt pathway, promotes the phosphorylation of histone H2AX and induces G2/M arrest in the cell cycle.
-
体外实验——
-
体内实验——
-
同义词ON-01910
-
通路Apoptosis
-
靶点Apoptosis
-
受体Apoptosis|BCR-ABL|Cdk1|Flt1|Fyn|PDGFR|PLK1|PLK2|Src
-
研究领域——
-
适应症——
化学信息
-
CAS Number592542-59-1
-
分子量451.49
-
分子式C21H25NO8S
-
纯度>98% (HPLC)
-
溶解度DMSO:75 mg/mL (166.12 mM; Need ultrasonic)
-
SMILESCOC1=C(C=C(C=C1)CS(=O)(=O)/C=C/C2=C(C=C(C=C2OC)OC)OC)NCC(=O)O
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Xu F, et al. Rigosertib as a selective anti-tumor agent can ameliorate multiple dysregulated signalingtransduction pathways in high-grade myelodysplastic syndrome. Sci Rep. 2014 Dec 4;4:7310.
产品手册
关联产品
-
MC4033
MC4033 是一种选择性的，可逆的赖氨酸乙酰转移酶8(KAT8) 抑制剂，其 IC50 值为 12.1 μM。MC4033 具有抗癌活性。MC4033 可诱导凋亡 (apoptosisautophagy)。
-
PRDX1-IN-1
PRDX1-IN-1 is a selective inhibtor of PRDX1 with an IC50 value of 0.164 μM. PRDX1-IN-1 can be used in researches related to cancer.PRDX1-IN-1 promots intracellular ROS accumulation, and inhibits the proliferation, invasion and migration of cancer cells besides inducing apoptosis. PRDX1-IN-1 could be used in cancer research.
-
DC_AC50
DC_AC50 是 Atox1 和 CCS（铜伴侣）的双重抑制剂。
