Ridinilazole

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

瑞地尼拉唑是一种新型窄谱不可吸收抗生素。

Ridinilazole is a novel narrow-spectrum nonabsorbable antibiotic. Ridinilazole showed potent inhibition of C. difficile (MIC90=0.125 mg/L) and was markedly more active than either metronidazole (MIC90?=?8 mg/L) or vancomycin (MIC90?=?2 mg/L).ridinilazole , a novel antibacterial currently under development for the treatment of CDI.?Owing to its highly targeted spectrum of activity and ability to spare the normal gut microbiota, ridinilazole provides significant advantages over metronidazole and vancomycin, the mainstay antibiotics for CDI.?Ridinilazole is bactericidal against C. difficile and exhibits a prolonged post-antibiotic effect.?Furthermore, treatment with ridinilazole results in decreased toxin production.(In Vitro):Ridinilazole is a novel antibacterial that does not appear to act through the classical pathways associated with antibiotics, such as inhibition of cell wall, protein, lipid, RNA or DNA synthesis. Ridinilazole may impair cell division. Ridinilazole is bactericidal against C.?difficile and exhibits a prolonged post-antibiotic effect. In susceptibility testing of 82 clinical isolates of C.?difficile (including ribotype 027), Ridinilazole displays potent growth inhibition and has lower MICs [MIC range, 0.06-0.25?μg/mL; MIC for 90% of the organisms (MIC90), 0.125?μg/mL] than Metronidazole (MIC range, 0.125-8?μg/mL; MIC90, 8?μg/mL) or Vancomycin (MIC range, 0.5-4?μg/mL; MIC90, 2?μg/mL). Similarly, Ridinilazole is found to be more potent than Metronidazole or Vancomycin at inhibiting the growth of 50 ribotype-defined C.?difficile strains. The activity of Ridinilazole against specific C.?difficile ribotypes (including ribotypes 001, 002, 005, 014, 027, 054 and 106) is similar, with an MIC range of 0.06–0.5?μg/mL and an MIC90 of 0.125?μg/mL. In addition, Ridinilazole is more active against 11 ribotype 027 strains than either Metronidazole or Vancomycin.(In Vivo):In a hamster model of CDI with a once-daily dosing regimen, Ridinilazole displays greater efficacy than Vancomycin both against non-epidemic and epidemic strains of C.?difficile. Similar to the twice-daily dosing study, plasma levels of Ridinilazole are below the level of detection, whereas caecal Ridinilazole concentrations are well above the MIC, thus demonstrating the non-absorbable nature of Ridinilazole and minimal systemic exposure.

Ridinilazole is a novel antibacterial that does not appear to act through the classical pathways associated with antibiotics, such as inhibition of cell wall, protein, lipid, RNA or DNA synthesis. Ridinilazole may impair cell division. Ridinilazole is bactericidal against C.?difficile and exhibits a prolonged post-antibiotic effect. In susceptibility testing of 82 clinical isolates of C.?difficile (including ribotype 027), Ridinilazole displays potent growth inhibition and has lower MICs [MIC range, 0.06-0.25?μg/mL; MIC for 90% of the organisms (MIC90), 0.125?μg/mL] than Metronidazole (MIC range, 0.125-8?μg/mL; MIC90, 8?μg/mL) or Vancomycin (MIC range, 0.5-4?μg/mL; MIC90, 2?μg/mL). Similarly, Ridinilazole is found to be more potent than Metronidazole or Vancomycin at inhibiting the growth of 50 ribotype-defined C.?difficile strains. The activity of Ridinilazole against specific C.?difficile ribotypes (including ribotypes 001, 002, 005, 014, 027, 054 and 106) is similar, with an MIC range of 0.06–0.5?μg/mL and an MIC90 of 0.125?μg/mL. In addition, Ridinilazole is more active against 11 ribotype 027 strains than either Metronidazole or Vancomycin.

In a hamster model of CDI with a once-daily dosing regimen, Ridinilazole displays greater efficacy than Vancomycin both against non-epidemic and epidemic strains of C.?difficile. Similar to the twice-daily dosing study, plasma levels of Ridinilazole are below the level of detection, whereas caecal Ridinilazole concentrations are well above the MIC, thus demonstrating the non-absorbable nature of Ridinilazole and minimal systemic exposure.

SMT19969

GPCR/G Protein

Antibacterial

Antibacterial

Immune system

Clostridium Difficile Infection

308362-25-6

388.42

C24H16N6

>98% (HPLC)

DMSO:55 mg/mL (141.6 mM)

c1cc(ccn1)-c1nc2cc(ccc2[nH]1)-c1ccc2[nH]c(nc2c1)-c1ccncc1

——

(-20℃)

With Ice Pack

≥ 2 years