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Rhein
CAS No. 478-43-3
Rhein ( NSC 38629 | Rheic Acid )
产品货号. M14595 CAS No. 478-43-3
大黄酸是一种广泛存在于草药中的亲脂性蒽醌，具有多种药理作用，包括胃肠保护、肾保护、抗炎、抗氧化、抗癌和抗菌活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | ￥405 | 有现货 |
|
| 200MG | ￥640 | 有现货 |
|
| 500MG | ￥1280 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Rhein
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述大黄酸是一种广泛存在于草药中的亲脂性蒽醌，具有多种药理作用，包括胃肠保护、肾保护、抗炎、抗氧化、抗癌和抗菌活性。
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产品描述Rhein is a lipophilic anthraquinone extensively found in medicinal herbs, and has many pharmacological effects, including epatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities.
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体外实验RT-PCR Cell Line:acute promyelocytic leukemia (APL) cell (NB4 cells) Concentration:5 μM Incubation Time:72 h Result:Increaseed mRNA expression of PU.1, C/EBPA, and C/EBPE.Increaseed ATRA activated mRNA expression of CCR1 and CCR2.Western Blot Analysis Cell Line:NB4 cells Concentration:0-40 μM Incubation Time:48 and 72 h Result:Increased the expression of cleaved caspase-3, Bax.Decreased the expression of Bcl-xl, procaspase-3.
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体内实验Animal Model:2.5 g/kg APAP (i.g.) induced rats Dosage:10, 20 and 40 mg/kg Administration:i.g.Result:Ameliorated histopathological damage of liver and kidney.Reduced GPT, GOT, UREA and CREA levels and ROS production.Restored NO, MDA, GSH contents.
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同义词NSC 38629 | Rheic Acid
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通路Autophagy
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靶点Other Targets
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受体Others
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研究领域Other Indications
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适应症——
化学信息
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CAS Number478-43-3
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分子量284.22
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分子式C10H13N5O3
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纯度>98% (HPLC)
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溶解度Ethanol: <1 mg/mL (<1 mM); Water: <1 mg/mL (<1 mM); DMSO: <1 mg/mL (<1 mM)
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SMILESO=C(C1=C2C=CC=C1O)C3=C(O)C=C(C(O)=O)C=C3C2=O
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化学全称4,5-Dihydroxyanthraquinone-2-carboxylic acid
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Xiaowen Chen, et al. Toll-like receptor 4 is involved in a protective effect of rhein on immunoglobulin A nephropathy. Indian J Pharmacol. 2015 Jan-Feb; 47(1): 27–33.
2. Hou ML, et al. The Drug-Drug Effects of Rhein on the Pharmacokinetics and Pharmacodynamics of Clozapine in Rat Brain Extracellular Fluid by In Vivo Microdialysis. J Pharmacol Exp Ther. 2015 Oct;355(1):125-34.
3. Yan-Xi Zhou, et al. Rhein: A Review of Pharmacological Activities. Evid Based Complement Alternat Med. 2015; 2015: 578107.
产品手册
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Rhein
大黄酸是一种广泛存在于草药中的亲脂性蒽醌，具有多种药理作用，包括胃肠保护、肾保护、抗炎、抗氧化、抗癌和抗菌活性。
