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Relebactam
CAS No. 1174018-99-5
Relebactam ( MK-7655 )
产品货号. M10588 CAS No. 1174018-99-5
Relebactam (MK-7655) 是一种新型 β-内酰胺酶抑制剂，可在体外抑制 A 类和 C 类 β-内酰胺酶。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥786 | 有现货 |
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| 10MG | ￥1256 | 有现货 |
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| 25MG | ￥2341 | 有现货 |
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| 50MG | ￥4358 | 有现货 |
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| 100MG | ￥6302 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Relebactam
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Relebactam (MK-7655) 是一种新型 β-内酰胺酶抑制剂，可在体外抑制 A 类和 C 类 β-内酰胺酶。
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产品描述Relebactam (MK-7655)?is a novel β-lactamase inhibitor that inhibited both class A and C β-lactamases in vitro; effectively restored imipenem's activity against imipenem-resistant Pseudomonas and Klebsiella strains at clinically achievable concentrations; reduces imipenem MICs for Enterobacteriaceae with KPC carbapenemases from 16-64 mg/L to 0.12-1 mg/L at a concentration of 4 mg/L.Bacterial Infection Phase 3 Clinical(In Vitro):Relebactam combine with Imipenem demonstrates activity against KPC-producing Enterobacteriaceae and multidrug-resistant P. aeruginosa.Relebactam shows limited inhibition of Class D-producing bacteria and has antipseudomonal activity.
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体外实验——
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体内实验——
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同义词MK-7655
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通路GPCR/G Protein
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靶点Antibacterial
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受体diazabicyclooctane
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研究领域Infection
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适应症Bacterial Infection
化学信息
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CAS Number1174018-99-5
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分子量348.3754
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分子式C12H20N4O6S
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=S(O)(ON1[C@]2([H])CC[C@@H](C(NC3CCNCC3)=O)[N@@](C2)C1=O)=O
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化学全称Sulfuric acid, mono[(1R,2S,5R)-7-oxo-2-[(4-piperidinylamino)carbonyl]-1,6-diazabicyclo[3.2.1]oct-6-yl] ester
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Hirsch EB, et al. Antimicrob Agents Chemother. 2012 Jul;56(7):3753-7.
2. Blizzard TA, et al. Bioorg Med Chem Lett. 2014 Feb 1;24(3):780-5.
3. Livermore DM, et al. J Antimicrob Chemother. 2013 Oct;68(10):2286-90.
