Rebamipide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

瑞巴派特是2-(1H)-喹啉酮的氨基酸衍生物，用于粘膜保护、胃十二指肠溃疡愈合和胃炎治疗。

Rebamipide, an amino acid derivative of 2-(1H)-quinolinone, is used for mucosal protection, healing of gastroduodenal ulcers, and treatment of gastritis. It works by enhancing mucosal defense, scavenging free radicals, and temporarily activating genes encoding cyclooxygenase-2.

Cell Proliferation Assay Cell Line:AGS cells Concentration:1.4, 2.7, 5.4 mM Incubation Time:24 h Result:Significant decreased in cell proliferation in a concentration-dependent manner.Western Blot Analysis Cell Line:AGS cells Concentration:5.4 mM Incubation Time:30 min or 3 h Result:Significantly increased phosphorylation of Smad2/3 by 1.2-fold when at 30 min and formation of Smad2/3-Smad4 complex by 1.4-fold.Upregulated expression of p21 protein by 2.5-fold when at 3 h.

Animal Model:Specific pathogen-free male Sprague-Dawley rats (200-230 g; 7-week-old).Dosage:5, 15, 50 mg/kg Administration:Oral administration; once daily for 14 days.Result:Increased the level of COX-2 immunoreactivity and PGE2 in a dose-dependent manner. (PGE2 is implicated in protection of gastric mucosa from various insults and acceleration of gastric wound healing).Inhibited intragastric HCl administration-induced gastric mucosal bleeding and erosion.

OPC 12759

NF-κB

Free radical scavengers

Free radical scavengers

Neurological Disease

——

90098-04-7

370.79

C19H15ClN2O4

>98% (HPLC)

DMSO: 74 mg/mL (199.57 mM)

O=C(O)C(NC(C1=CC=C(Cl)C=C1)=O)CC2=CC(NC3=C2C=CC=C3)=O

2-(4-chlorobenzamido)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid

(-20℃)

With Ice Pack

≥ 2 years