Rasarfin ( —— )

产品货号. M28668 CAS No. 674359-73-0

Rasarfin 抑制 Ras 和 ARF6。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
2MG	￥640	有现货
5MG	￥988	有现货
10MG	￥1596	有现货
25MG	￥2908	有现货
50MG	￥4836	有现货
100MG	￥6901	有现货
500MG	￥14013	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Rasarfin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Rasarfin 抑制 Ras 和 ARF6。
产品描述

Rasarfin inhibits Ras and ARF6.(In Vitro):Rasarfin resulted in a dose-dependent reduction in cell growth in MDA-MB-231 cells.After 48 and 72?h of treatment, Rasarfin modestly decreased in a dose-dependent manner the metabolic activity of cancer cells compared to cells treated with DMSO.However, compared to Doxorubicin which potently killed cells, cell viability was not affected by Rasarfin treatment. Rasarfin inhibited proliferation of A549 lung cancer cells, which have increased Ras and EGFR activity52. Similar to the anti-proliferative effect on MDA-MB-231 cells, A549 cell growth inhibition at 5 and 10?μM of Rasarfin,more important cell viability effects of Rasarfin on A549 cells than MDA-MB-231 cells at 10?μM of Rasarfin treatment.
体外实验

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体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

EGFR
研究领域

——
适应症

——

化学信息

CAS Number

674359-73-0
分子量

425.91
分子式

C23H24ClN3O3
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 50 mg/mL (117.40 mM)
SMILES

CC(C)C(N(CC1)CCN1c(ccc(NC(c1cc(cccc2)c2o1)=O)c1)c1Cl)=O
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Wang A, et al. Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode.

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册