SMIFH2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SMIFH2 是福尔马林同源 2 (FH2) 结构域抑制剂。

SMIFH2 is formin homology 2 (FH2) domains inhibitor.

SMIFH2 (25 uM; 1-16 hours) induces dynamic cytoskeletal remodelling in U2OS cells. SMIFH2 (25 μM) reduces p300, mDia2 and p53 levels in a proteasome-independent manner.SMIFH2 reduces expression and activity of p53 through a post-transcriptional, proteasome-independent mechanism that influences remodelling of the cytoskeleton. Western Blot Analysis Cell Line:293T, A375, U2OS, and MDA-MB-231 cells Concentration:25 μM Incubation Time:5 hours for 293T, U2OS, MDA-MB-231 cells; 2.5 hours for A375 cells Result:Downregulated mDia2, p53 and p300 protein levels.

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Others

Other Targets

mGluR5

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340316-62-3

377.21

C15H9BrN2O3S

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (331.38 mM)

Brc1cccc(c1)N1C(=S)NC(=O)\C(=C/c2ccco2)C1=O

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(-20℃)

With Ice Pack

≥ 2 years