RVX-297 ( RVX297 )

产品货号. M10223 CAS No. 1044871-04-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

RVX-297
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

RVX-297 is a novel orally active, BD2 selective, BET bromodomain inhibitor.
产品描述

RVX-297 is a novel orally active, BD2 selective, BET bromodomain inhibitor with Alpha Screen IC50 of 0.08, 0.05 and 0.02 uM for BRD2 (BD2), BRD3 (BD2) and BRD4 (BD2), respectively; displays about 50-fold selectivity over BD1; suppresses inflammatory gene expression in multiple immune cell types in culture; reduces pro-inflammatory mediators assessed in splenic gene expression and serum proteins in LPS model of inflammation.
同义词

RVX297
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

——
适应症

——

CAS Number

1044871-04-6
分子量

423.51
分子式

C24H29N3O4
纯度

>98% (HPLC)
溶解度

——
SMILES

COC1=C(C(NC(C2=CC(C)=C(OCCN3CCCC3)C(C)=C2)=N4)=O)C4=CC(OC)=C1
化学全称

2-(3,5-dimethyl-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,7-dimethoxyquinazolin-4(3H)-one

1. Kharenko OA, et al. Biochem Biophys Res Commun. 2016 Aug 12;477(1):62-7.

计算器

产品手册

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