ROC-325 ( ROC 325;ROC325 )

产品货号. M12869 CAS No. 1859141-26-6

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

ROC-325
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

ROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy.
产品描述

ROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy; exhibits superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in different cancer cell lines, including accumulation of autophagosomes with undegraded cargo, lysosomal deacidification, p62 stabilization, and disruption of autophagic flux; antagonizes RCC growth and survival in an ATG5/7-dependent manner, induces apoptosis and exhibited favorable selectivity; significantly more effective at inhibiting tumor progression than HCQ, and inhibited autophagy in vivo.
同义词

ROC 325;ROC325
通路

Autophagy
靶点

Autophagy
受体

Autophagy
研究领域

Cancer
适应症

——

CAS Number

1859141-26-6
分子量

503.06
分子式

C28H27ClN4OS
纯度

>98% (HPLC)
溶解度

DMSO : 32 mg/mL 63.61 mM; H2O : < 0.1 mg/mL
SMILES

O=C1C2=C(C(C)=CC=C2NCCN(C)CCNC3=C(C=CC(Cl)=C4)C4=NC=C3)SC5=CC=CC=C51
化学全称

1-((2-((2-((7-chloroquinolin-4-yl)amino)ethyl)(methyl)amino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one

1. Carew JS, et al. Clin Cancer Res. 2017 Jun 1;23(11):2869-2879.
2. Carew JS, et al. Autophagy. 2017 Apr 3;13(4):765-766.

计算器

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