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RO3
CAS No. 1026582-88-6
RO3 ( —— )
产品货号. M22083 CAS No. 1026582-88-6
RO3 是同聚 P2X3 和异聚 P2X2/3 受体的选择性拮抗剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2001 | 有现货 |
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| 10MG | ￥3013 | 有现货 |
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| 25MG | ￥5095 | 有现货 |
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| 50MG | ￥7258 | 有现货 |
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| 100MG | ￥9882 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称RO3
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述RO3 是同聚 P2X3 和异聚 P2X2/3 受体的选择性拮抗剂。
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产品描述RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor.
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体外实验——
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体内实验In a guinea pig ureter-afferent nerve preparation, and mouse bladder-pelvic nerve preparation, RO-3 dose-dependently reduces afferent nerve activity induced by distension or α,β-meATP.RO-3 has activity in several rodent models of pain, as well as in cystometry models optimized to measure various parameters associated with sensory regulation of the micturition reflex.RO-3 has moderate to high metabolic stability in rat and human hepatocytes and liver microsomes, and is highly permeable, orally bioavailable (14%), and has a reasonable in vivo plasma half-life (t1/2=0.41?h) in rats.
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同义词——
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通路Neuroscience
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靶点P2 Receptor
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受体P2X3
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研究领域——
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适应症——
化学信息
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CAS Number1026582-88-6
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分子量302.38
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分子式C16H22N4O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 125 mg/mL (413.40 mM)
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SMILESCOc1cc(Cc2cnc(N)nc2N)c(cc1OC)C(C)C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Gever J R , Cockayne D A , Dillon M P , et al. Pharmacology of P2X channels[J]. Pflügers Archiv European Journal of Physiology, 2006, 452(5):513-37.
