RIPK2-IN-2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种有效的选择性受体相互作用蛋白 2 (RIP2) 激酶抑制剂。

A potent, selective receptor interacting protein-2 (RIP2) kinase inhibitor.

RIP2 kinase inhibitor 2 is a novel prodrug of a quinazolyl amine that inhibits RIP2 kinase. Receptor interacting protein-2 (RIP2) kinase is a TKL family serine/threonine protein kinase involved in innate immune signaling. Following activation, RIP2 kinase associates with NODI or NOD2 and appears to function principally as a molecular scaffold to bring together other kinases (TAK1, ΙΚΚα/β/γ) involved in NF-κΒ and mitogen-activated protein kinase activation.

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RIPK2-IN-2 | RIPK2 IN 2 | RIPK2IN2 | RIPK2 inhibitor-2 | RIPK2 inhibitor 2

Apoptosis

RIP kinase

RIP kinase

Cancer

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1581270-11-2

432.5364

C21H28N4O4S

>98% (HPLC)

10 mM in DMSO

COCCOC1=C(S(=O)(C(C)(C)C)=O)C=C2C(NC3=NNC(C)=C3C)=CC=NC2=C1

4-Quinolinamine, 6-[(1,1-dimethylethyl)sulfonyl]-N-(4,5-dimethyl-1H-pyrazol-3-yl)-7-(2-methoxyethoxy)-

(-20℃)

With Ice Pack

≥ 2 years