GSK-843

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GSK-843 (GSK'843) 是一种受体相互作用蛋白激酶 3 (RIP3 or RIPK3) 抑制剂，高亲和力结合 RIP3 激酶结构域，IC50 值为 8.6 nM，并抑制激酶活性 IC50 值为 6.5 nM。GSK-843 可用于炎症的研究。

GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM. GSK-843 can be used for the research of inflammation.

GSK-843 (3-10 μM; 18 h) induces apoptosis.GSK-843 (0.3-3 μM; 18 h) suppresses TNF-induced death and virus-induced cell necrosis. Cell Viability Assay Cell Line:SVEC, L929, 3T3SA and mouse embryo fibroblast (MEF)Concentration:3 and 10 μM Incubation Time:18 hours Result:Decreased the cell viability of SVEC, L929, 3T3SA and MEF cells, and induced caspase activation followed by apoptotic cell death.Cell Viability Assa Cell Line:3T3-SA and SVEC4-10 cells Concentration:0.3, 1 and 3 μM Incubation Time:18 hours Result:Dose-dependently suppressed TNF-induced death and virus-induced necrosis to improved cell viability.

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Apoptosis

RIP kinase

RIP kinase

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1601496-05-2

377.49

C19H15N5S2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 50 mg/mL (132.45 mM; 超声助溶 )

Cc1cc(-c2cnc(N)c3c(csc23)-c2ccc3scnc3c2)n(C)n1

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(-20℃)

With Ice Pack

≥ 2 years