RIPGBM

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

RIGBM 是一种细胞类型选择性的小分子细胞凋亡诱导剂，可诱导 GBM 癌症干细胞 (CSC) 凋亡，EC50 为 220 nM（GBM 1 细胞）。

RIPGBM is a cell type-selective, small molecule inducer of apoptosis in GBM cancer stem cells (CSCs) with EC50 of 220 nM (GBM 1 cells); RIPGBM is converted to an apoptosis-inducing derivative (cRIPGBM/RIPGBM-18) selectively in GBM CSCs; cRIPGBM induces apoptosis in GBM CSCs by interacting with RIPK2; significantly suppress tumor formation in vivo in orthotopic intracranial GBM CSC tumor xenograft mouse model.

RIPGBM induces caspase 1-dependent apoptosis by binding to receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch, which reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex.

——

——

Apoptosis

RIP kinase

RIP kinase

——

——

355406-76-7

428.463

C26H21FN2O3

>98% (HPLC)

In Vitro:?DMSO : 33.33 mg/mL (77.79 mM)

CC(=O)N(CC1=CC=C(C=C1)F)C2=C(C(=O)C3=CC=CC=C3C2=O)NCC4=CC=CC=C4

N-(3-(benzylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-N-(4-fluorobenzyl)acetamide

(-20℃)

With Ice Pack

≥ 2 years