QTX125 ( QTX 125;QTX-125 )

产品货号. M11154 CAS No. 1279698-31-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

QTX125
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

QTX125 (QTX-125) is a novel potent, selective HDAC6 inhibitor, displays excellent selectivity over other HDACs.
产品描述

QTX125 (QTX-125) is a novel potent, selective HDAC6 inhibitor, displays excellent selectivity over other HDACs; strongly reduces cell viability with IC50 values of 0.120 and 0.182 uM in two primary samples obtained from patients with MCL; causes cell-growth inhibition and programmed cell death in association with increased levels of acetylated α-tubulin, also antitumoral effect is particularly evident in MCL models, both in culture and in vivo, surpassing the efficacy of currently available HDAC6 inhibitors.
同义词

QTX 125;QTX-125
通路

Cell Cycle/DNA Damage
靶点

HDAC
受体

HDAC
研究领域

——
适应症

——

CAS Number

1279698-31-5
分子量

417.42
分子式

C23H19N3O5
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(C1=C(C2=COC=C2)C=C(C3=CC=C(O)C=C3)N1)NCC4=CC=C(C(NO)=O)C=C4
化学全称

3-(3-furyl)-N-{4-[(hydroxyamino)carbonyl]benzyl}-5-(4-hydroxyphenyl)-1H-pyrrole2-carboxamide

1. Perez-Salvia M, et al. Haematologica. 2018 Jun 7. pii: haematol.2018.189241.

计算器

产品手册

关联产品

Remodelin

A potent inhibitor of the acetyl-transferase protein NAT10 that acetylates both histones and microtubules.
Droxinostat

Droxinostat (NS-41080) is a selective HDAC inhibitor with IC50 of 16.9, 2.47 and 1.46 uM for HDAC3, HDAC6 and HDAC8, respectively.
BRD9757

BRD9757 is a potent, selective HDAC6 inhibitor with IC50 of 8 nM.