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Q203
CAS No. 1334719-95-7
Q203 ( Q-203;Q 203;IAP6;Telacebec )
产品货号. M11336 CAS No. 1334719-95-7
A novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB, inhibits M. tuberculosis H37Rv with MIC50 of of 2.7 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1312 | 有现货 |
|
| 10MG | ￥2041 | 有现货 |
|
| 25MG | ￥3669 | 有现货 |
|
| 50MG | ￥5403 | 有现货 |
|
| 100MG | ￥7687 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Q203
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB, inhibits M. tuberculosis H37Rv with MIC50 of of 2.7 nM.
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产品描述A novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB, inhibits M. tuberculosis H37Rv with MIC50 of of 2.7 nM; does not inhibit any of thecytochrome P450 (CYP450) isoenzymes; targets the respiratory cytochrome bc1 complex and triggers a rapid ATP depletion in M. tuberculosis, also inhibits the growth of MDR and XDR M. tuberculosis; deonstrates potency in mouse model of tuberculosis and displays pharmacokinetic and safety profiles.Bacterial Infection Phase 1 Clinical
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同义词Q-203;Q 203;IAP6;Telacebec
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通路GPCR/G Protein
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靶点Antibacterial
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受体MycobacteriumtuberculosisH37Rv
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研究领域Infection
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适应症Bacterial Infection
化学信息
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CAS Number1334719-95-7
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分子量557.01
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分子式C29H28ClF3N4O2
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纯度>98% (HPLC)
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溶解度DMSO: 10 mM
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SMILESCCC1=C(N2C=C(C=CC2=N1)Cl)C(=O)NCC3=CC=C(C=C3)N4CCC(CC4)C5=CC=C(C=C5)OC(F)(F)F
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化学全称Imidazo[1,2-a]pyridine-3-carboxamide, 6-chloro-2-ethyl-N-[[4-[4-[4-(trifluoromethoxy)phenyl]-1-piperidinyl]phenyl]methyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Pethe K, et al. Nat Med. 2013 Sep;19(9):1157-60.
2. Kang S, et al. J Med Chem. 2014 Jun 26;57(12):5293-305.
3. Jang J, et al. Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e02637-16.
2. Kang S, et al. J Med Chem. 2014 Jun 26;57(12):5293-305.
3. Jang J, et al. Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e02637-16.
产品手册
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