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Pyrazoloacridine
CAS No. 99009-20-8
Pyrazoloacridine ( PD 115934; PD-115934; PD 115,934; NSC 366140; NSC-366140 )
产品货号. M27918 CAS No. 99009-20-8
Pyrazoloacridine is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1191 | 有现货 |
|
| 10MG | ￥1936 | 有现货 |
|
| 25MG | ￥3872 | 有现货 |
|
| 50MG | ￥5581 | 有现货 |
|
| 100MG | ￥7954 | 有现货 |
|
| 500MG | ￥15876 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Pyrazoloacridine
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Pyrazoloacridine is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity.
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产品描述Pyrazoloacridine is a nucleic acid binding agent that inhibits the activity of topo I and II with an IC50 of 1.25 μM in K562 cells. Pyrazoloacridine shows anti-cancer activity.(In Vitro):In oxic and hypoxic HCT-8 cells, Pyrazoloacridine exhibits IC50 values of 10.7 μM and 4.5 μM. Pyrazoloacridine causes delayed DNA fragmentation in MCF-7 cells and induces apoptosis in P53-deficient Hep 3B cells. Pyrazoloacridine exhibits activities against cisplatin- and paclitaxel-resistant ovarian cancer.
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同义词PD 115934; PD-115934; PD 115,934; NSC 366140; NSC-366140
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通路Apoptosis
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靶点Apoptosis
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受体Akt;PP2A;Apoptosis;CIP2A
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研究领域——
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适应症——
化学信息
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CAS Number99009-20-8
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分子量367.4
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分子式C19H21N5O3
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纯度>98% (HPLC)
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溶解度——
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SMILESCOc1ccc2[nH]c3c(ccc4n(CCCN(C)C)nc(c34)c2c1)[N+]([O-])=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Chun-Yu Liu, et al. EGFR-independent Elk1/CIP2A signalling mediates apoptotic effect of an erlotinib derivative TD52 in triple-negative breast cancer cells. Eur J Cancer. 2017 Feb;72:112-123.
产品手册
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