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Prunetin

CAS No. 552-59-0

Prunetin ( —— )

产品货号. M18796 CAS No. 552-59-0

Prunetin 显着降低脂多糖攻击小鼠的血清炎症细胞因子水平和死亡率。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥721 有现货
10MG ¥1256 有现货
25MG ¥2130 有现货
100MG 获取报价 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Prunetin
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Prunetin 显着降低脂多糖攻击小鼠的血清炎症细胞因子水平和死亡率。
  • 产品描述
    Prunetin significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesity-related transcription through a feedback mechanism that regulates the expression of adiponectin, adipoR1, adipoR2, and AMPK. Prunetin and biochanin A are potent reducers of NF-κB and ERK activation, zonula occludens 1 tyrosine phosphorylation, and metalloproteinase-mediated shedding activity, which may account for the barrier-improving ability of these isoflavones. Prunetin significantly suppresses ATP-induced mucin secretion from cultured RTSE cells; Prunetin inhibits the production of MUC5AC mucin protein induced by EGF or PMA from NCI-H292 cells; Prunetin also inhibits the expression of MUC5AC mucin gene induced by EGF or PMA from NCI-H292 cells.
  • 体外实验
    Prunetin inhibited LPS-induced inflammatory cytokine production and MUC5?AC expression and secretion by inactivating the TLR4/MyD88 pathway in human nasal epithelial cells.
  • 体内实验
    ——
  • 同义词
    ——
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    NF-κB|ERK
  • 研究领域
    Others-Field
  • 适应症
    ——

化学信息

  • CAS Number
    552-59-0
  • 分子量
    284.26
  • 分子式
    C16H12O5
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : 100 mg/mL (351.79 mM)
  • SMILES
    COC1=CC(=C2C(=C1)OC=C(C2=O)C3=CC=C(C=C3)O)O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

产品手册
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