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IP7e

CAS No. 500164-74-9

IP7e ( IP 7e;IP-7e;isoxazolo-pyridinone 7e )

产品货号. M27887 CAS No. 500164-74-9

IP7e is a Nurr1 activator with an EC50 value of 3.9 nM.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥3208 有现货
10MG ¥4771 有现货
25MG ¥7655 有现货
50MG ¥10368 有现货
100MG ¥14013 有现货
500MG ¥28026 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    IP7e
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    IP7e is a Nurr1 activator with an EC50 value of 3.9 nM.
  • 产品描述
    IP7e is a Nurr1 activator with an EC50 value of 3.9 nM.(In Vivo):IP7e(10 mg/kg) attenuates inflammation and neurodegeneration in spinal cords of EAE mice by an NF-kB pathway-dependent process. IP7e preventive treatment reduces the incidence and the severity of an MS murine model, i.e. experimental autoimmune encephalomyelitis (EAE).
  • 同义词
    IP 7e;IP-7e;isoxazolo-pyridinone 7e
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    ACMSD
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    500164-74-9
  • 分子量
    390.4
  • 分子式
    C23H22N2O4
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    COCCOCc1ccc(cc1)-c1cc2onc(-c3ccccc3)c2c(=O)n1C
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Pellicciari R, et al. α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis. J Med Chem. 2018 Feb 8;61(3):745-759.
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