Progabide ( SL 76002; Halogabide; Gabren; Gabrene )

产品货号. M26795 CAS No. 62666-20-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Progabide
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Progabide is an agonist of the gamma-aminobutyric acid receptor.
产品描述

Progabide is an agonist of the gamma-aminobutyric acid receptor.(In Vivo):Progabide ( 50, 100 and 200 mg/kg) given IP to male Wistar rats enhance the plasma corticosterone levels by 244, 365, and 476% respectively (t=6.44 to12.55, p<0.01). Progabide (10 mg/kg) fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). Compare with the corresponding control, The greatest corticosterone rise is reached 60 min following the administration of Progabide.
同义词

SL 76002; Halogabide; Gabren; Gabrene
通路

Others
靶点

Other Targets
受体

Kv2.2
研究领域

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适应症

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1.Herrington J, et al. Identification of novel and selective Kv2 channel inhibitors. Mol Pharmacol. 2011 Dec;80(6):959-64.

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