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Pivanex

CAS No. 122110-53-6

Pivanex ( AN-9 | Pivalyloxymethyl butyrate )

产品货号. M26790 CAS No. 122110-53-6

Pivanex 是一种口服活性 HDAC 抑制剂和抗转移剂和抗血管生成剂。 Pivanex 下调 Bcr-Abl 蛋白并增强细胞凋亡。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥316 有现货
10MG ¥478 有现货
25MG ¥988 有现货
50MG ¥1531 有现货
100MG ¥2333 有现货
200MG ¥3467 有现货
500MG ¥5557 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Pivanex
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Pivanex 是一种口服活性 HDAC 抑制剂和抗转移剂和抗血管生成剂。 Pivanex 下调 Bcr-Abl 蛋白并增强细胞凋亡。
  • 产品描述
    Pivanex is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis.(In Vitro):In K562 cells, Pivanex (100-500 μM) exhibits significant anti-proliferation activity and enhances apoptosis and caspase activity. Pivanex (200 μM) induces enhancement in the G2-M phase, a moderate enhancement in the S phase, and a slight reduction in G0-G1 of the cell cycle.(In Vivo):Pivanex(200 mg/kg, b.i.d, daily) treatment marked delays in the end stage of disease as defined by the onset of body mass loss by 94.9%. Pivanex(200 mg/kg, b.i.d, daily) obviously improves the survival of SMN7 SMA mice by 84.6%.
  • 体外实验
    Pivanex (100-500 μM) exhibits significant anti-proliferation activity in K562 cells.Pivanex (100-500 μM) also enhances apoptosis and caspase activity in K562 cells.Pivanex (200 μM)induces enhancement in the G2-M phase, a moderate enhancement in the S phase and a slight reduction in G0-G1 of the cell cycle.Pivanex (AN-9) has selective toxicity to acute leukemia and drug-resistant primary leukemia and cancer cell lines. Cell Viability Assay Cell Line:K562 cells.Concentration:100-500 μM.Incubation Time:24 hours.Result:Reduced the number of K562 viable cells significantly.100 μM Pivanex with 0.125 or 0.25 μM STI571 reduced the number of viable cells synergistically.Apoptosis Analysis Cell Line:K562 cells.Concentration:100-500 μM.Incubation Time:6-72 hours.Result:Increased the number of K562 apoptotic cells significantly.Increased the caspase activity in K562 cells significantly after only 4 h of incubation with 500 μM.
  • 体内实验
    Pivanex (AN9, 200 mg/kg, b.i.d, daily) significantly improves the survival of SMN7 SMA mice. Pivanex (AN9) treatment also marked delays the end stage of disease as defined by the onset of body mass loss. Animal Model:SMN7 SMA mice (SMN2+/+; SMN7+/+; mSmn?/?).Dosage:200 mg/kg.Administration:Oral administration, b.i.d, at 09.00 and 17.00 daily.Result:Improved the mean lifespan of treated SMN7 SMA mice by 84.6%.Delayed the onset of body mass loss in SMN7 SMA mice by 94.9%.
  • 同义词
    AN-9 | Pivalyloxymethyl butyrate
  • 通路
    Apoptosis
  • 靶点
    Apoptosis
  • 受体
    GSK-3α| GSK-3β
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    122110-53-6
  • 分子量
    202.25
  • 分子式
    C10H18O4
  • 纯度
    >98% (HPLC)
  • 溶解度
    In Vitro:?DMSO : ≥ 100 mg/mL (494.44 mM)
  • SMILES
    CCCC(=O)OCOC(=O)C(C)(C)C
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Prabhakaran J, et al. Radiosynthesis and in Vivo Evaluation of [11C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain. ACS Chem Neurosci. 2017 Aug 16;8(8):1697-1703.
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