Phenformin ( —— )

产品货号. M33658 CAS No. 114-86-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

Phenformin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Phenformin (1-phenethylbiguanide) 是一种具有口服活性的抗糖尿病和抗癌化合物。Phenformin 有相关乳酸性酸中毒的发生率。Phenformin 通过激活 AMPK 并阻断 mTOR 通路发挥作用。Phenformin 也是 P-糖蛋白 (P-gp) 的底物和 OXPHOS 抑制剂。Phenformin 诱导癌细胞凋亡 (apoptosis)。
产品描述

Phenformin (1-phenethylbiguanide) is an orally active antidiabetic and anticancer agent. Phenformin has an incidence of associated lactic acidosis. Phenformin acts through acting AMPK activation and blocking mTOR pathway. Phenformin is also a substrate of P-glycoprotein (P-gp), and an OXPHOS inhibitor. Phenformin induces cancer cell apoptosis.
体外实验

——
体内实验

——
同义词

——
通路

Apoptosis
靶点

Apoptosis
受体

Apoptosis
研究领域

——
适应症

——

1. García Rubi?o ME, et al. Phenformin as an Anticancer Agent: Challenges and Prospects. Int J Mol Sci. 2019 Jul 5;20(13):3316.?

计算器

产品手册

关联产品

3-Deoxyaconitine

3-?脱氧乌头碱是乌头碱 (A189875) 的衍生物，可激活河豚毒素敏感的 Na+ 通道，诱导突触前去极化。
Bigelovin

Bigelovin 是一种选择性视黄醇 X 受体 α 激动剂。 Bigelovin 通过抑制 ROS 生成调节的 mTOR 通路，诱导细胞凋亡和自噬，从而抑制肿瘤生长。它也被称为来自旋覆花属的有效细胞毒性倍半萜内酯。
Se-Aspirin

Se-Aspirin (Se-NSAID-8) has anticancer activity and gastroprotective effects, inhibits activation of proinflammatory and pro-survival NF-?B pathways, and inhibits the expression of anti-apoptotic targets downstream of NF-?B (e.g., Bcl-xL, Mcl-1, and survivin).Se-Aspirin induces Cell cycle arrest and activation of apoptosis accelerates ulcer healing and can be used to study pancreatic and colorectal cancer.