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PU-02
CAS No. 313984-77-9
PU-02 ( 6-[(1-Naphthalenylmethyl)thio]-9H-purine )
产品货号. M21984 CAS No. 313984-77-9
PU-02 是一种有效的选择性 5-HT3 受体拮抗剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥446 | 有现货 |
|
| 10MG | ￥786 | 有现货 |
|
| 25MG | ￥1531 | 有现货 |
|
| 50MG | ￥2811 | 有现货 |
|
| 100MG | ￥4496 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PU-02
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PU-02 是一种有效的选择性 5-HT3 受体拮抗剂。
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产品描述PU-02 is a potent and selective antagonist of 5-HT3 receptor.
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体外实验PU02 (NMMP) (0-200 μM) leads to a steady decrease in cell viability of HepG2 cells (IC50=48.585 μM). PU02 (NMMP) shows less toxicity on L02 cells than did 6-MP after 48 h of treatment.PU02 (NMMP) at 6.25 or 25 μM exhibits inhibitory effects on the viability of the tested cell lines, including SMMC-7721, MDA-MB-231, RKO and HCT-8 cells.PU02 (NMMP) induces cell cycle arrest at the G2/M phase. PU02 (NMMP) downregulats the expression of cyclin B1/D1 and CDK4 in a time-dependent manner in HepG2 cells,but the expression of cyclin E is not affected.PU02 (NMMP)-treated cells exhibits a significant increase in caspase-3 cleavage, suggesting enhanced apoptotic activity. Apoptosis AnalysisCell Line:HepG2 cells.Concentration:6.26, 12.5, 25, 50 μM.Incubation Time:6, 12, 24, 36 h.Result:Induced mitochondria-dependent apoptosis.
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体内实验——
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同义词6-[(1-Naphthalenylmethyl)thio]-9H-purine
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通路Endocrinology/Hormones
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靶点5-HT Receptor
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受体5-HT3
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研究领域——
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适应症——
化学信息
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CAS Number313984-77-9
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分子量292.36
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分子式C16H12N4S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 250 mg/mL (855.11 mM)
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SMILESC(Sc1ncnc2nc[nH]c12)c1cccc2ccccc12
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Trattnig S M , Harpsoe K , Thygesen S B , et al. Discovery of a Novel Allosteric Modulator of 5-HT3 Receptors: INHIBITION AND POTENTIATION OF CYS-LOOP RECEPTOR SIGNALING THROUGH A CONSERVED TRANSMEMBRANE INTERSUBUNIT SITE[J]. Journal of Biological Chemistry, 2012, 287(30):25241-25254.
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