PSI

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PSI 是一种蛋白酶体抑制剂。

PSI is a proteasome inhibitor.

PSI (24 h) inhibits the proliferation of primary effusion lymphoma (PEL) cells at low nanomolar concentrations (CC50s of 205, 190, 22.0, 53.0 nM FOR BJAB, Ramos, BC3, BCBL1 cells, respectively).PSI (50 nM; 6 h) increases caspase-3/7 activity by 8-fold compared with control.PSI (50 nM; 6 h) decreases the transcriptional activity of NF-κB by 52%.PSI (1, 5 nM; 3 days) inhibits the growth of BC3 cells at a high concentration (5 nM). Cell Cytotoxicity Assay Cell Line:BC3, BCBL1, Ramos, BJAB cells Concentration:Incubation Time:24 h Result:Inhibited the proliferation of primary effusion lymphoma (PEL) cells at low nanomolar concentrations (CC50s of 205, 190, 22.0, 53.0 nM FOR BJAB, Ramos, BC3, BCBL1 cells, respectively).Western Blot Analysis Cell Line:HBL6 cells Concentration:50 nM Incubation Time:6 h Result:Decreased the NF-κB activity by 52%.

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Proteasome/Ubiquitin

Proteasome

nitric oxide

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158442-41-2

618.76

C32H50N4O8

>98% (HPLC)

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C[C@@H](C(NC([C@H](CCC(OC(C)(C)C)=O)NC([C@H]([C@@H](C)CC)N)=O)=O)=O)N(C(OCC1=CC=CC=C1)=O)[C@H](C=O)CC(C)C

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(-20℃)

With Ice Pack

≥ 2 years