(1S,2S)-Bortezomib

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(1S,2S)-硼替佐米是硼替佐米的对映体。 Bortezomib 是一种可逆的选择性蛋白酶体抑制剂，20S 蛋白酶体的 Ki 值为 0.6 nM。

(1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a reversible and selective inhibitor of the proteasome with a Ki of 0.6 nM for 20S proteasome.(In Vitro):Bortezomib disrupts the cell cycle, induces apoptosis, inhibits NF-κB, and possesses anti-cancer capacity.

——

——

Bortezomib

Proteasome/Ubiquitin

Proteasome

Non-cleavable

——

——

1132709-14-8

384.24

C19H25BN4O4

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (130.13 mM)

[C@H](CC1=CC=CC=C1)(C(N[C@H](CC(C)C)B(O)O)=O)NC(=O)C=2C=NC=CN2

——

(-20℃)

With Ice Pack

≥ 2 years