PHCCC ( PHCCC )

产品货号. M17377 CAS No. 179068-02-1

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HNMR

HPLC

MSDS

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产品名称

PHCCC
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

PHCCC is a Group I metabotropic glutamate receptor antagonist and a positive allosteric modulator of mGluR4. It also is a potent to antagonism for mGluR2 and mGluR8.
产品描述

PHCCC is a positive allosteric modulator of mGluR4. PHCCC exhibits proconvulsant action in three models of epileptic seizures in immature rats. PHCCC reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors. PHCCC showed neuroprotection against betaAP- and NMDA-toxicity in mixed cultures of mouse cortical neurons. This neuroprotection was additive to that induced by the highly efficacious mGluR1 antagonist CPCCOEt and was blocked by MSOP, a group-III mGluR antagonist. Our data provide evidence for a novel pharmacological site on mGluR4, which may be used as a target-site for therapeutics.
同义词

PHCCC
通路

Endocrinology/Hormones
靶点

5-HT Receptor
受体

mGluR1
研究领域

Cancer
适应症

——

CAS Number

179068-02-1
分子量

294.31
分子式

C17H14N2O3
纯度

98%
溶解度

DMSO : ≥ 32 mg/mL; 108.73 mM
SMILES

C12(C(/C(=N/O)/c3ccccc3O1)C2)C(=O)Nc1ccccc1
化学全称

(E)-7-(hydroxyimino)-N-phenyl-7,7a-dihydrocyclopropa[b]chromene-1a(1H)-carboxamide

1.Marino MJ et al.Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13668-73.

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