PHCCC

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PHCCC 是 I 类代谢型谷氨酸受体拮抗剂和 mGluR4 的正变构调节剂。它还具有强效拮抗 mGluR2 和 mGluR8 的作用。

PHCCC is a positive allosteric modulator of mGluR4. PHCCC exhibits proconvulsant action in three models of epileptic seizures in immature rats. PHCCC reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors. PHCCC showed neuroprotection against betaAP- and NMDA-toxicity in mixed cultures of mouse cortical neurons. This neuroprotection was additive to that induced by the highly efficacious mGluR1 antagonist CPCCOEt and was blocked by MSOP, a group-III mGluR antagonist. Our data provide evidence for a novel pharmacological site on mGluR4, which may be used as a target-site for therapeutics.

PHCCC potentiated the effect of L-(+)-2-amino-4-phosphonobutyric acid (L-AP4) in inhibiting transmission at the striatopallidal synapse.

PHCCC (75 nmol/2.5 μl; intracerebroventricular) produces an antiparkinsonian effect in a dopamine depletion akinesia model.

PHCCC

Endocrinology/Hormones

5-HT Receptor

mGluR1

Cancer

——

179068-02-1

294.31

C17H14N2O3

>98% (HPLC)

DMSO : ≥ 32 mg/mL; 108.73 mM

C12(C(/C(=N/O)/c3ccccc3O1)C2)C(=O)Nc1ccccc1

(E)-7-(hydroxyimino)-N-phenyl-7,7a-dihydrocyclopropa[b]chromene-1a(1H)-carboxamide

(-20℃)

With Ice Pack

≥ 2 years