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PFI-3
CAS No. 1819363-80-8
PFI-3 ( PF-6687252;PF-06687252 )
产品货号. M12801 CAS No. 1819363-80-8
PFI-3 is a potent and cell active BRG/PB1 bromodomains inhibitor with Kd of 54-97 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥365 | 有现货 |
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| 5MG | ￥575 | 有现货 |
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| 10MG | ￥851 | 有现货 |
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| 25MG | ￥1782 | 有现货 |
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| 50MG | ￥2714 | 有现货 |
|
| 100MG | ￥4034 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PFI-3
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PFI-3 is a potent and cell active BRG/PB1 bromodomains inhibitor with Kd of 54-97 nM.
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产品描述PFI-3 is a potent and cell active BRG/PB1 bromodomains inhibitor with Kd of 54-97 nM; shows high selectivity over other bromodomains; exposure of embryonic stem cells to PFI-3 led to deprivation of stemness and deregulated lineage specification; markedly enhances the differentiation of trophoblast stem cells; attenuates adipocyte differentiation and dramatically decreases lipid accumulation; a first in class chemical probe for Family VIII bromodomains.
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同义词PF-6687252;PF-06687252
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通路Chromatin/Epigenetic
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靶点Bromodomain
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受体PB1(5)bromodomains;SMARCA2;SMARCA4
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研究领域Cancer
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适应症——
化学信息
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CAS Number1819363-80-8
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分子量321.38
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分子式C19H19N3O2
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纯度>98% (HPLC)
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溶解度DMSO: 32.1 mg/mL (100 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESOC1=C(C(/C=C/N2[C@H](C3)CN(C4=NC=CC=C4)[C@H]3C2)=O)C=CC=C1
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化学全称(E)-1-(2-hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Fedorov O, et al. Sci Adv. 2015 Nov 13;1(10):e1500723.
2. Vangamudi B, et al. Cancer Res. 2015 Sep 15;75(18):3865-78.
3. Gerstenberger BS, et al. J Med Chem. 2016 May 26;59(10):4800-11.
2. Vangamudi B, et al. Cancer Res. 2015 Sep 15;75(18):3865-78.
3. Gerstenberger BS, et al. J Med Chem. 2016 May 26;59(10):4800-11.
