GSK8814 ( GSK 8814;GSK-8814 )

产品货号. M13118 CAS No. 1997369-78-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

GSK8814
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GSK8814 is a potent, selective inhibitor of ATAD2/2B bromodomain binding constant pKd of 8.1 in ITC assays.
产品描述

GSK8814 is a potent, selective inhibitor of ATAD2/2B bromodomain binding constant pKd of 8.1 in ITC assays; displaces acetylated H4 peptide from the ATAD2 bromodomain with pIC50 of 7.3 and is also active in BROMOscan with pKi of 8.9, displays >100 fold selective over all other bromodomains and >1,000 fold selective over BRD4; shows cellular target engagement with an EC50 of 2 μM in a NanoBRET assay evaluating the interaction of the NanoLuc-ATAD2 bromodomain with histone H3.3-HaloTag.
同义词

GSK 8814;GSK-8814
通路

Chromatin/Epigenetic
靶点

Bromodomain
受体

Bromodomain
研究领域

——
适应症

——

CAS Number

1997369-78-4
分子量

527.62
分子式

C28H35F2N5O3
纯度

>98% (HPLC)
溶解度

——
SMILES

CC(C(N1)=O)=CC2=C1C(N[C@H]3[C@H](OCC4CCC(F)(F)CC4)CNC[C@@H]3OC)=NC=C2C5=CN=CC(C)=C5
化学全称

8-(((3R,4R,5S)-3-((4,4-difluorocyclohexyl)methoxy)-5-methoxypiperidin-4-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one

计算器

产品手册

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