PF-9363

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PF-9363 是一种有效的高选择性 KAT6A/KAT6B 抑制剂。 PF-9363可用于癌症研究。

PF-9363 is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.

PF-9363 (0~1 μM; 1 day; ZR75-1, T47D and MCF7 cells) down-regulates the expression of H3K23Ac biomarker.PF-9363 leads to down regulation of a specific set of genes involved in ESR1 pathway, cell cycle and stem cell pathways. PF-9363 shows that the IC50 values for ZR75-1 and T47D are 0.3 nM and 0.9 nM. Western Blot Analysis Cell Line:ZR75-1, T47D and MCF7 cells Concentration:0~1 μM Incubation Time:1 day Result:Down-regulated the expression of H3K23Ac biomarker.

PF-9363 shows strong anti-tumor activity in patient-derived xenograft models.

CTX-3648

Chromatin/Epigenetic

Histone Demethylase

KAT6A/KAT6B

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2569009-58-9

444.46

C20H20N4O6S

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (112.50 mM)

O=S(C1=C(OC)C=CC=C1OC)(NC2=NOC3=C2C(OC)=CC(CN4N=CC=C4)=C3)=O

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(-20℃)

With Ice Pack

≥ 2 years