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PF-06446846
CAS No. 1632250-49-7
PF-06446846 ( —— )
产品货号. M22373 CAS No. 1632250-49-7
PF?06446846 is a potent and selective PCSK9 inhibitor?PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.?
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1077 | 有现货 |
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| 5MG | ￥1588 | 有现货 |
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| 10MG | ￥2390 | 有现货 |
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| 25MG | ￥4398 | 有现货 |
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| 50MG | ￥6342 | 有现货 |
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| 100MG | ￥8829 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PF-06446846
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PF?06446846 is a potent and selective PCSK9 inhibitor?PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.?
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产品描述PF?06446846 is a potent and selective PCSK9 inhibitor?PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.?PF-06446846 is highly selective for the inhibition of PCSK9 translation.?The mechanism of action employed by PF-06446846 reveals a previously unexpected tunability of the human ribosome that allows small molecules to specifically block translation of individual transcripts.
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同义词——
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通路Others
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靶点Other Targets
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受体PCSK9
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研究领域——
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适应症——
化学信息
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CAS Number1632250-49-7
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分子量433.9
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分子式C22H20ClN7O
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纯度>98% (HPLC)
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溶解度——
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SMILESClc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-n1nnc2cccnc12
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Lintner N G , Mcclure K F , Donna P , et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain[J]. PLoS Biology, 2017, 15(3):e2001882-.
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