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Sarolaner

CAS No. 1398609-39-6

Sarolaner ( PF-6450567 )

产品货号. M23553 CAS No. 1398609-39-6

Sarolaner 是一种口服活性广谱杀体外寄生虫剂(针对 C. felis 的 LC80:0.3 μg/mL,针对 O. turicata 的 LC100:0.003 μg/mL)。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥786 有现货
10MG ¥1442 有现货
25MG ¥3062 有现货
50MG ¥4601 有现货
100MG ¥6602 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Sarolaner
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Sarolaner 是一种口服活性广谱杀体外寄生虫剂(针对 C. felis 的 LC80:0.3 μg/mL,针对 O. turicata 的 LC100:0.003 μg/mL)。
  • 产品描述
    Sarolaner is an orally active and broad-spectrum ectoparasiticide (LC80: 0.3 μg/mL against C. felis and an LC100: 0.003 μg/mL against O. turicata).
  • 体外实验
    Cell Viability Assay Cell Line:CHO-K1 cell lines Concentration:450 nM-1 mM Incubation Time:5 min Result:Inhibited GABA-elicited currents at both susceptible (CfRDL-A285) and resistant (CfRDL-S285) flea GABACls with EC50s of 135 and 136 nM, respectively.
  • 体内实验
    Animal Model:Dog infested with R. sanguineus and D. reticulatus Dosage:2.5 mg/kg Administration:Oral gavage; 2.5 mg/kg once Result:Exibited 100% efficacy against R. sanguineus at 48 hours after treatment and also exhibited 98.0% efficacy against D. reticulatus.Animal Model:Dog infested with I. ricinus Dosage:1.25, 2.5 and 5 mg/kg Administration:Oral gavage; 1.25, 2.5 and 5 mg/kg once Result:Exibited 100% efficacy against I. ricinus at all doses until 7 days, and provided over 99.3% reduction against subsequent re-infestations until 57 days at dose of 5.0 and 2.5 mg/kg.
  • 同义词
    PF-6450567
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    LC80|LC100
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1398609-39-6
  • 分子量
    581.36
  • 分子式
    C23H18Cl2F4N2O5S
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO : 290 mg/mL (498.83 mM; Need ultrasonic)
  • SMILES
    O=S(CC(N1CC2(OCC3=C2C=CC(C4=NO[C@](C(F)(F)F)(C5=CC(Cl)=C(F)C(Cl)=C5)C4)=C3)C1)=O)(C)=O
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.McTier TL, et al. Discovery of sarolaner: A novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs. Vet Parasitol. 2016 May 30;222:3-11.
产品手册
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