Sarolaner
CAS No. 1398609-39-6
Sarolaner ( PF-6450567 )
产品货号. M23553 CAS No. 1398609-39-6
Sarolaner 是一种口服活性广谱杀体外寄生虫剂(针对 C. felis 的 LC80:0.3 μg/mL,针对 O. turicata 的 LC100:0.003 μg/mL)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ¥786 | 有现货 |
|
| 10MG | ¥1442 | 有现货 |
|
| 25MG | ¥3062 | 有现货 |
|
| 50MG | ¥4601 | 有现货 |
|
| 100MG | ¥6602 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Sarolaner
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述Sarolaner 是一种口服活性广谱杀体外寄生虫剂(针对 C. felis 的 LC80:0.3 μg/mL,针对 O. turicata 的 LC100:0.003 μg/mL)。
-
产品描述Sarolaner is an orally active and broad-spectrum ectoparasiticide (LC80: 0.3 μg/mL against C. felis and an LC100: 0.003 μg/mL against O. turicata).
-
体外实验Cell Viability Assay Cell Line:CHO-K1 cell lines Concentration:450 nM-1 mM Incubation Time:5 min Result:Inhibited GABA-elicited currents at both susceptible (CfRDL-A285) and resistant (CfRDL-S285) flea GABACls with EC50s of 135 and 136 nM, respectively.
-
体内实验Animal Model:Dog infested with R. sanguineus and D. reticulatus Dosage:2.5 mg/kg Administration:Oral gavage; 2.5 mg/kg once Result:Exibited 100% efficacy against R. sanguineus at 48 hours after treatment and also exhibited 98.0% efficacy against D. reticulatus.Animal Model:Dog infested with I. ricinus Dosage:1.25, 2.5 and 5 mg/kg Administration:Oral gavage; 1.25, 2.5 and 5 mg/kg once Result:Exibited 100% efficacy against I. ricinus at all doses until 7 days, and provided over 99.3% reduction against subsequent re-infestations until 57 days at dose of 5.0 and 2.5 mg/kg.
-
同义词PF-6450567
-
通路Others
-
靶点Other Targets
-
受体LC80|LC100
-
研究领域——
-
适应症——
化学信息
-
CAS Number1398609-39-6
-
分子量581.36
-
分子式C23H18Cl2F4N2O5S
-
纯度>98% (HPLC)
-
溶解度DMSO : 290 mg/mL (498.83 mM; Need ultrasonic)
-
SMILESO=S(CC(N1CC2(OCC3=C2C=CC(C4=NO[C@](C(F)(F)F)(C5=CC(Cl)=C(F)C(Cl)=C5)C4)=C3)C1)=O)(C)=O
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
-
PKC ζ pseudosubstrat...
Inhibitor of protein kinase C (PKC) ζ; attached to cell permeabilisation Antennapedia domain vector peptide. Consists of amino acids 113 - 129 of PKC ζ pseudosubstrate domain linked by a disulphide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the inhibitor peptide. Once inside the cell, the disulphide bonds are subjected to reduction in the cytoplasm leading to release of the inhibitor peptide. Induces mast cell degranulation by a PKC ζ-independent pathway.
-
Physostigmine
Physostigmine (Eserine) 是一种可逆的乙酰胆碱酯酶 (AChE) 抑制剂。Physostigmine 可以透过血脑屏障并刺激中枢胆碱能神经传递。Physostigmine 能逆转阿尔茨海默病转基因小鼠的记忆缺陷。Physostigmine 也是抗胆碱能中毒的解毒剂。
-
trans-2-Undecenoic a...
反式-2-十一烯酸 ((E)-2-十一烯酸) 是一种 α,β-不饱和羧酸,其特征为酸二聚体。
021-51111890
购物车()
sales@molnova.cn

