• 咨询热线
    客服服务热线 13671568941/15317326293
  • 在线咨询
  • 微信客服
    微信客服
  • 公众号
    扫码关注公众号

PF-06282999

CAS No. 1435467-37-0

PF-06282999 ( PF06282999;PF 06282999 )

产品货号. M11851 CAS No. 1435467-37-0

A potent, highly selective and irreversible inhibitor of myeloperoxidase (MPO).

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
2MG ¥348 有现货
5MG ¥583 有现货
10MG ¥988 有现货
25MG ¥2001 有现货
50MG ¥3216 有现货
100MG ¥4771 有现货
200MG 获取报价 有现货
500MG 获取报价 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    PF-06282999
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    A potent, highly selective and irreversible inhibitor of myeloperoxidase (MPO).
  • 产品描述
    A potent, highly selective and irreversible inhibitor of myeloperoxidase (MPO) with Kinact/KI of 116000 M-1s-1; displays high selectivity for MPO over TPO and cytochrome P450 isoforms; shows excellent pharmacological and pharmacokinetic profile; orally active. Thrombosis Phase 1 Clinical
  • 同义词
    PF06282999;PF 06282999
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Myeloperoxidase
  • 研究领域
    Cardiovascular Disease
  • 适应症
    Thrombosis

化学信息

  • CAS Number
    1435467-37-0
  • 分子量
    325.77
  • 分子式
    C13H12ClN3O3S
  • 纯度
    >98% (HPLC)
  • 溶解度
    DMSO: ≥ 32 mg/mL
  • SMILES
    O=C(N)CN(C(N1)=S)C(C2=CC(Cl)=CC=C2OC)=CC1=O
  • 化学全称
    1(2H)-Pyrimidineacetamide, 6-(5-chloro-2-methoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Ruggeri RB, et al. J Med Chem. 2015 Nov 12;58(21):8513-28.
2. Dong JQ, et al. Drug Metab Dispos. 2016 Feb;44(2):209-19.
产品手册
关联产品
  • Kaempferol 3-sophoro...

    Kaempferol 3-sophoroside-7-rhamnoside is a natural product.

  • BQ-3020 TFA (143113-...

    BQ-3020 (TFA) is a selective ETB receptor agonist that inhibits [125I] et-1 binding to the ETB receptor in the cerebellum with a 0.2nm IC50, causing vasoconstriction.

  • Apohyoscine

    Apohyoscine is a natural product of Datura, Solanaceae. Apohyoscine can be used as a reference standard.