PF-06282999
CAS No. 1435467-37-0
PF-06282999 ( PF06282999;PF 06282999 )
产品货号. M11851 CAS No. 1435467-37-0
A potent, highly selective and irreversible inhibitor of myeloperoxidase (MPO).
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
2MG | ¥348 | 有现货 |
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5MG | ¥583 | 有现货 |
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10MG | ¥988 | 有现货 |
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25MG | ¥2001 | 有现货 |
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50MG | ¥3216 | 有现货 |
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100MG | ¥4771 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PF-06282999
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述A potent, highly selective and irreversible inhibitor of myeloperoxidase (MPO).
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产品描述A potent, highly selective and irreversible inhibitor of myeloperoxidase (MPO) with Kinact/KI of 116000 M-1s-1; displays high selectivity for MPO over TPO and cytochrome P450 isoforms; shows excellent pharmacological and pharmacokinetic profile; orally active. Thrombosis Phase 1 Clinical
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同义词PF06282999;PF 06282999
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通路Others
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靶点Other Targets
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受体Myeloperoxidase
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研究领域Cardiovascular Disease
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适应症Thrombosis
化学信息
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CAS Number1435467-37-0
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分子量325.77
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分子式C13H12ClN3O3S
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 32 mg/mL
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SMILESO=C(N)CN(C(N1)=S)C(C2=CC(Cl)=CC=C2OC)=CC1=O
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化学全称1(2H)-Pyrimidineacetamide, 6-(5-chloro-2-methoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Ruggeri RB, et al. J Med Chem. 2015 Nov 12;58(21):8513-28.
2. Dong JQ, et al. Drug Metab Dispos. 2016 Feb;44(2):209-19.
2. Dong JQ, et al. Drug Metab Dispos. 2016 Feb;44(2):209-19.
产品手册
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