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PF-04895162
CAS No. ——
PF-04895162 ( ICA-105665 | PF 04895162 | ICA105665 | PF 4895162 )
产品货号. M16958 CAS No. ——
PF-04895162 (ICA-105665, PF 4895162) 是一种口服的神经元 Kv7 钾通道激动剂，可打开 Kv7.2/7.3 和 Kv7.3/7.5 钾通道。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PF-04895162
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PF-04895162 (ICA-105665, PF 4895162) 是一种口服的神经元 Kv7 钾通道激动剂，可打开 Kv7.2/7.3 和 Kv7.3/7.5 钾通道。
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产品描述PF-04895162 (ICA-105665, PF 4895162) is an orally available agonist of neuronal Kv7 potassium channel, opens Kv7.2/7.3 and Kv7.3/7.5 potassium channels, also known as KCNQ2/3 and KCNQ3/5 channels; ICA-105665 has demonstrated broad spectrum antiseizure activity in multiple animal models including maximal electroshock, 6 Hz seizures, pentylenetetrazole, and electrical kindling at doses from <1 to 5 mg/kg.Epilepsy Phase 1 Discontinued.
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体外实验——
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体内实验——
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同义词ICA-105665 | PF 04895162 | ICA105665 | PF 4895162
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通路Cell Cycle/DNA Damage
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靶点Potassium Channel
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受体Potassium Channel
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研究领域——
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适应症——
化学信息
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CAS Number——
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分子量355.345
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分子式C19H15F2N3O2
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称N-(2-cyclopropyl-7-fluoro-4-oxoquinazolin-3(4H)-yl)-2-(4-fluorophenyl)ethanamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kasteleijn-Nolst Trenité DG, et al. Epilepsia. 2013 Aug;54(8):1437-43.
2. Aleo MD, et al. Pharmacol Res Perspect. 2019 Feb;7(1):e00467.
3. Bialer M, et al. Epilepsy Res. 2013 Jan;103(1):2-30.
4. Roeloffs R, et al. J Pharmacol Exp Ther. 2008 Sep;326(3):818-28.
产品手册
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