PF-03246799 ( PF 03246799;PF03246799;PF-3246799 )

产品货号. M10282 CAS No. 1065110-62-4

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Datasheet

HNMR

HPLC

MSDS

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产品名称

PF-03246799
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent and selective 5-HT2C receptor agonist with EC50 of 190 nM, with excellent selectivity for 5-HT2C over 5-HT2A.
产品描述

A potent and selective 5-HT2C receptor agonist with EC50 of 190 nM, with excellent selectivity for 5-HT2C over 5-HT2A; has minimal activation at either the 5-HT(2A) or 5-HT(2B) receptors, demonstrates robust efficacy in preclinical canine model of stress urinary incontinence (SUI) and attractive pharmacokinetic and safety properties.
同义词

PF 03246799;PF03246799;PF-3246799
通路

Endocrinology/Hormones
靶点

5-HT Receptor
受体

5-HT Receptor
研究领域

——
适应症

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1. Andrews MD, et al. Bioorg Med Chem Lett. 2011 May 1;21(9):2715-20.
2. Dvorak CA, et al. ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8.

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