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PCI-24781
CAS No. 783355-60-2
PCI-24781 ( CRA 024781;CRA 24781;PCI 24781;Abexinostat )
产品货号. M15956 CAS No. 783355-60-2
A broad spectrum HDAC inhibitor; inhibits pure recombinant HDAC1 with Ki of 7 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥373 | 有现货 |
|
| 5MG | ￥583 | 有现货 |
|
| 10MG | ￥891 | 有现货 |
|
| 25MG | ￥1539 | 有现货 |
|
| 50MG | ￥2778 | 有现货 |
|
| 100MG | ￥4366 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PCI-24781
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述A broad spectrum HDAC inhibitor; inhibits pure recombinant HDAC1 with Ki of 7 nM.
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产品描述A broad spectrum HDAC inhibitor; inhibits pure recombinant HDAC1 with Ki of 7 nM; also inhibits HDAC2, HDAC3/SMRT, HDAC6, HDAC8, and HDAC10 in the nanomolar range; causes the accumulation of acetylated histone and acetylated tubulin in tumor cell lines; decreases RAD51 expression and inhibits homologous recombination.Blood Cancer Phase 2 Clinical
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同义词CRA 024781;CRA 24781;PCI 24781;Abexinostat
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通路Cell Cycle/DNA Damage
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靶点HDAC
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受体HDAC1;HDAC10;HDAC2;HDAC3/SMRT;HDAC6
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研究领域Cancer
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适应症Blood cancer
化学信息
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CAS Number783355-60-2
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分子量397.42
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分子式C21H23N3O5
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纯度>98% (HPLC)
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溶解度10 mM in DMSO
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SMILESO=C(C(O1)=C(CN(C)C)C2=C1C=CC=C2)NCCOC3=CC=C(C(NO)=O)C=C3
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化学全称2-Benzofurancarboxamide, 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
2. Adimoolam S, et al. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19482-7.
3. Salvador MA, et al. Clin Cancer Res. 2013 Dec 1;19(23):6520-31.
产品手册
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