Oxychlororaphine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

氧氯拉芬强烈抑制链霉菌属的生长。

Oxychlororaphine inhibits strongly the growth of Streptomyces sp. 441.

Oxychloroaphine (1-256 μM; 24 h) has cytotoxicity with IC50 values for A549, HeLa, and SW480 cancer cell lines between 32 and 40 μM.Oxychloroaphine (1-150 μM; A549, HeLa, and SW480 cancer cell lines) causes cell membrane damage, leading to increase apoptosis and leakage of lactate dehydrogenase, and increases production of cytochrome c protein.Oxychloroaphine (32 μM; A549 and SW480 cells) induces cycle arrest at G1 phase and induction of sub-G phase.Oxychloroaphine (48 h; A549 cells) induces downregulation of antiapoptotic Bcl-2 protein and the activation of proapoptotic protein caspase-3 led to the cleavage of PARP. Cell Viability AssayCell Line:A549, HeLa, and SW480 cancer cell lines Concentration:1, 2, 4, 8, 16, 32, 64, 128, and 256 μM Incubation Time:24 hours Result:Inhibited cell proliferative in a dose-dependent manner.

——

phenazine-1-carboxamide

GPCR/G Protein

Antibacterial

Carboxylesterase

——

——

550-89-0

223.235

C13H9N3O

>98% (HPLC)

In Vitro:?DMSO : 10 mg/mL (44.80 mM)

NC(=O)c1cccc2nc3ccccc3nc12

——

(-20℃)

With Ice Pack

≥ 2 years