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Oxybenzone
CAS No. 131-57-7
Oxybenzone ( Oxybenzone, Benzophenone-3, 2-hydroxy-4-methoxybenzone, Eusolex-4360 )
产品货号. M11279 CAS No. 131-57-7
氧苯酮是一种用于防晒霜的有机化合物。它是二苯甲酮的衍生物。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | ￥348 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Oxybenzone
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述氧苯酮是一种用于防晒霜的有机化合物。它是二苯甲酮的衍生物。
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产品描述Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone. It forms colorless crystals that are readily soluble in most organic solvents. It is used as an ingredient in sunscreen and other cosmetics because it absorbs UV-A ultraviolet rays. (In Vitro):Oxybenzone (Benzophenone 3) (25 μM; 24 hours) decreases the relative RXRβ and RXRγ protein levels by 61 and 56%, respectively and increases the relative RXRα protein level by 49%.Oxybenzone (25-100 μM; 24 hours) induces an increase in caspase-3 levels in primary cultures of mouse neocortical cells at 7 DIV. Oxybenzone-induced apoptosis involves the activation of RXRα signaling and the impairment of RXRβ/RXRγ signaling. Oxybenzone (25 μM; 24 hours) inhibits global DNA methylation as well as reduced HDAC and HAT activities in mouse embryonic neuronal cells.
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体外实验Oxybenzone (Benzophenone 3) (25 μM; 24 hours) decreases the relative RXRβ and RXRγ protein levels by 61 and 56%, respectively and increases the relative RXRα protein level by 49%.Oxybenzone (25-100 μM; 24 hours) induces an increase in caspase-3 levels in primary cultures of mouse neocortical cells at 7 DIV. Oxybenzone-induced apoptosis involves the activation of RXRα signaling and the impairment of RXRβ/RXRγ signaling. Oxybenzone (25 μM; 24 hours) inhibits global DNA methylation as well as reduced HDAC and HAT activities in mouse embryonic neuronal cells. Western Blot Analysis Cell Line:Mouse neocortical cells at 7 DIV Concentration:25 μM Incubation Time:24 hours Result:Exposure to Oxybenzone (25 μM) for 24 h decreased the relative RXRβ and RXRγ protein levels by 61 and 56%, respectively. Treatment with Oxybenzone (25 μM) increased the relative RXRα protein level by 49%.
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体内实验——
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同义词Oxybenzone, Benzophenone-3, 2-hydroxy-4-methoxybenzone, Eusolex-4360
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number131-57-7
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分子量228.24
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分子式C14H12O3
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纯度>98% (HPLC)
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溶解度Water: 69 mg/L .
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SMILESO=C(C1=CC=C(OC)C=C1O)C2=CC=CC=C2
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化学全称(2-hydroxy-4-methoxyphenyl)-phenylmethanone
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Gonzalez H, et al. Br J Dermatol. 2006 Feb;154(2):337-40.
