GLN-1062
CAS No. 224169-27-1
GLN-1062 ( Memogain )
产品货号. M26751 CAS No. 224169-27-1
GLN-1062 is a pro-drug of galantamine and liberates galantamine on cleavage by a carboxyesterase in the brain.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥1256 | 有现货 |
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10MG | ¥2001 | 有现货 |
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25MG | ¥4034 | 有现货 |
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50MG | ¥5873 | 有现货 |
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100MG | ¥7995 | 有现货 |
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500MG | ¥16038 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称GLN-1062
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述GLN-1062 is a pro-drug of galantamine and liberates galantamine on cleavage by a carboxyesterase in the brain.
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产品描述GLN-1062 is a pro-drug of galantamine and liberates galantamine on cleavage by a carboxyesterase in the brain.(In Vivo):GLN-1062 has more than 15-fold higher bioavailability in the brain than the same doses of galantamine. In animal models of drug-induced amnesia, GLN-1062 produced several fold larger cognitive improvement than the same doses of galantamine, without exhibiting any significant levels of gastrointestinal side effects that are typical for the unmodified drug and other inhibitors of cholinesterases, such as donepezil and rivastigmin. In the ferret, dramatically reduced emetic and behavioral responses were observed when GLN-1062 was administered instead of galantamine.
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同义词Memogain
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通路Others
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靶点Other Targets
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受体Farnesyl transferase (FTase)
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研究领域——
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适应症——
化学信息
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CAS Number224169-27-1
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分子量391.5
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分子式C24H25NO4
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纯度>98% (HPLC)
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溶解度——
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SMILES[H][C@]12C[C@@H](OC(=O)c3ccccc3)C=C[C@]11CCN(C)Cc3ccc(OC)c(O2)c13
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Stacy L Moulder, et al. A phase I open label study of the farnesyltransferase inhibitor CP-609,754 in patients with advanced malignant tumors. Clin Cancer Res. 2004 Nov 1;10(21):7127-35.
产品手册
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