GLN-1062 ( Memogain )

产品货号. M26751 CAS No. 224169-27-1

GLN-1062 是加兰他敏的前药，在大脑中被羧酸酯酶裂解后释放加兰他敏。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥1256	有现货
10MG	￥2001	有现货
25MG	￥4034	有现货
50MG	￥5873	有现货
100MG	￥7995	有现货
500MG	￥16038	有现货
1G	获取报价	有现货

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生物学信息

产品名称

GLN-1062
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

GLN-1062 是加兰他敏的前药，在大脑中被羧酸酯酶裂解后释放加兰他敏。
产品描述

GLN-1062 is a pro-drug of galantamine and liberates galantamine on cleavage by a carboxyesterase in the brain.(In Vivo):GLN-1062 has more than 15-fold higher bioavailability in the brain than the same doses of galantamine. In animal models of drug-induced amnesia, GLN-1062 produced several fold larger cognitive improvement than the same doses of galantamine, without exhibiting any significant levels of gastrointestinal side effects that are typical for the unmodified drug and other inhibitors of cholinesterases, such as donepezil and rivastigmin. In the ferret, dramatically reduced emetic and behavioral responses were observed when GLN-1062 was administered instead of galantamine.
体外实验

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体内实验

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同义词

Memogain
通路

Others
靶点

Other Targets
受体

Farnesyl transferase (FTase)
研究领域

——
适应症

——

化学信息

CAS Number

224169-27-1
分子量

391.467
分子式

C24H25NO4
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 100 mg/mL (255.45 mM)
SMILES

[H][C@]12C[C@@H](OC(=O)c3ccccc3)C=C[C@]11CCN(C)Cc3ccc(OC)c(O2)c13
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Stacy L Moulder, et al. A phase I open label study of the farnesyltransferase inhibitor CP-609,754 in patients with advanced malignant tumors. Clin Cancer Res. 2004 Nov 1;10(21):7127-35.

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