Omadacycline

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

奥马达环素是一种新型四环素抗生素，可以抑制细菌核糖体的30s亚基。

Omadacycline a new tetracycline antibiotic can inhibit the 30s subunit of bacterial ribosome.

Omadacycline displays activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), beta-hemolytic streptococci, penicillin-resistant Streptococcus pneumonia (PRSP) and Haemophilus influenzae (H. influenzae), with MIC90s of 1.0, 0.25, 0.5, 0.25 and 2.0 μg/mL respectively.Omadacycline is active against strains expressing tetracycline and other antibiotics resistance by ribosomal protection and active tetracycline efflux.

Omadacycline (0.11-18 mg/kg; a single i.v.) exhibits efficacy against Streptococcus pneumonia, Escherichia coli, and Staphylococcus aureus in mice systemic infection model, with ED50s ranging from 0.30 mg/kg to 3.39 mg/kg.

Amadacycline | PTK 0796

GPCR/G Protein

Antibacterial

ribosome 30s subunit

Inflammation/Immunology

Cystitis; Pyelonephritis; Urinary tract infections

389139-89-3

556.65

C29H40N4O7

>98% (HPLC)

DMSO: 10 mM

CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(cc(CNCC(C)(C)C)c(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)N(C)C

——

(-20℃)

With Ice Pack

≥ 2 years