Olorofim ( —— )

产品货号. M34247 CAS No. 1928707-56-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

Olorofim
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Olorofim（F-901318）is a novel selective antifungal compound targeting pyrimidine biosynthesis in mycobacteria, with inhibitory effect on Aspergillus fumigatus DHODH (IC50: 44 nM), but little inhibitory effect on human DHODH (>100 uM).Olorofim has good efficacy against a variety of pathogenic filamentous and dimorphic fungi, such as Penicillium spp, P. dermatitidis spp and Fusarium spp.
产品描述

Olorofim（F-901318）is a novel selective antifungal compound targeting pyrimidine biosynthesis in mycobacteria, with inhibitory effect on Aspergillus fumigatus DHODH (IC50: 44 nM), but little inhibitory effect on human DHODH (>100 uM).Olorofim has good efficacy against a variety of pathogenic filamentous and dimorphic fungi, such as Penicillium spp, P. dermatitidis spp and Fusarium spp.
体外实验

——
体内实验

——
同义词

——
通路

Metabolic Enzyme/Protease
靶点

Dehydrogenase
受体

Dehydrogenase | Antifungal
研究领域

——
适应症

——

CAS Number

1928707-56-5
分子量

498.55
分子式

C28H27FN6O2
纯度

>98% (HPLC)
溶解度

——
SMILES

C(C(NC1=CC=C(C=C1)N2CCN(CC2)C=3N=CC(F)=CN3)=O)(=O)C4=C(C=C(C)N4C)C5=CC=CC=C5
化学全称

——

计算器

产品手册

关联产品

Orotic acid

乳清酸（OA）是嘧啶代谢的中间体。乳清酸(6-羧基尿嘧啶)是一种杂环化合物和酸。
Mercaptopurine (6-MP...

巯嘌呤（6-巯基嘌呤；6-MP）是一种免疫抑制化合物。
11β-HSD1-IN-11

11β-HSD1-IN-11 (Compound c1a) 是一种竞争性的 11β-HSD1 抑制剂，对大鼠和人的 11β-HSD1 的 IC50 分别为 0.34 μM 和 0.13 μM。