021-51111890
购物车（）
sales@molnova.cn
OTX008
CAS No. 1638140-55-2
OTX008 ( Calixarene 0118;PTX-008 )
产品货号. M12472 CAS No. 1638140-55-2
OTX008 (Calixarene 0118, PTX-008) is a calixarene derivative designed to bind the Galectin-1 (Gal1) amphipathic β-sheet conformation.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称OTX008
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述OTX008 (Calixarene 0118, PTX-008) is a calixarene derivative designed to bind the Galectin-1 (Gal1) amphipathic β-sheet conformation.
-
产品描述OTX008 (Calixarene 0118, PTX-008) is a calixarene derivative designed to bind the Galectin-1 (Gal1) amphipathic β-sheet conformation; inhibits Gal1 expression and ERK1/2 and AKT-dependent survival pathways, and induces G2/M cell cycle arrest through CDK1; inhibits proliferation and invasion at micromolar concentrations in cancer cells; inhibits growth of A2780-1A9 xenografts in vivo.Solid Tumors Phase 1 Clinical
-
同义词Calixarene 0118;PTX-008
-
通路Cytoskeleton/Cell Adhesion Molecules
-
靶点Galectin
-
受体Galectin
-
研究领域Cancer
-
适应症Solid Tumors
化学信息
-
CAS Number1638140-55-2
-
分子量937.18
-
分子式C52H72N8O8
-
纯度>98% (HPLC)
-
溶解度——
-
SMILES——
-
化学全称Acetamide, 2,2',2'',2'''-[(2-methylpentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecaene-25,26,27,28-tetrayl)tetrakis(oxy)]tetrakis[N-[2-(dimethylamino)ethyl]-
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Dings RP, et al. J Med Chem. 2012 Jun 14;55(11):5121-9.
2. Astorgues-Xerri L, et al. Eur J Cancer. 2014 Sep;50(14):2463-77.
3. Dings RP, et al. Cancer Lett. 2008 Jul 8;265(2):270-80.
4. Zucchetti M, et al. Cancer Chemother Pharmacol. 2013 Oct;72(4):879-87.
2. Astorgues-Xerri L, et al. Eur J Cancer. 2014 Sep;50(14):2463-77.
3. Dings RP, et al. Cancer Lett. 2008 Jul 8;265(2):270-80.
4. Zucchetti M, et al. Cancer Chemother Pharmacol. 2013 Oct;72(4):879-87.
产品手册
关联产品
-
TD-139
TD-139 (TD139) is a highly potent, selecitve inhibitor of Galectin-3 (Gal-3) carbohydrate binding domain with Ki of 14 nM.
-
OTX008 (b)
OTX008 (Calixarene 0118, PTX-008) is a calixarene derivative designed to bind the Galectin-1 (Gal1) amphipathic β-sheet conformation.
-
GB1107
GB1107 (GB-1107, GB 1107) is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with Kd of 37 nM (human Galectin-3).
