O6-Benzylguanine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

O6-Benzylguanine 是一种具有抗肿瘤活性的鸟嘌呤类似物，是一种有效的 O6-烷基鸟嘌呤 DNA 烷基转移酶 (AGT) 灭活剂。

O6-Benzylguanine is a guanine analog with antineoplastic activityand?is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.

Western Blot Analysis Cell Line:L3.6pl and PANC1 cells Concentration:50 μg Incubation Time:48 hoursResult:Expressions of O6 methyl guanine DNA methyl transferase (MGMT), cyclin B1, cyclin B2, cyclin A, p53, and ki-67 were decreased, whereas p21 was increased. The levels of cyto C and caspase 9 were increased, whereas the levels of PARP1 protein were decreased. RT-PCR Cell Line:L3.6pl cells Concentration:50 μg Incubation Time:48 hours Result:Decreased the MGMT transcriptional activity in L3.6pl.

Animal Model:Male athymic nude mice (NCI-nu) (bearing human pancreatic cancer L3.6pl cells)Dosage:100 μg Administration:i.p; daily for 35 days Result:Significantly decreased median tumor volume and weight.

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Cell Cycle/DNA Damage

DNA Alkylator

O6-alkylguanine-DNA-alkyltransferas

Cancer

Brain Cancer; Glioblastoma; Glioma; Multiple myeloma; Sarcoma

19916-73-5

241.25

C12H11N5O

>98% (HPLC)

DMSO:48mg/mL(198.96mM)

Nc1nc(OCc2ccccc2)c2nc[nH]c2n1

6-(benzyloxy)-1H-purin-2-amine

(-20℃)

With Ice Pack

≥ 2 years