Nelotanserin ( APD-125;RVT-102 )

产品货号. M16119 CAS No. 839713-36-9

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

Nelotanserin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A potent, selective 5-HT2A inverse agonist with pKi of 9.2; displays >30- and 5000-fold selectivity compared with 5-HT2C and 5-HT2B receptors.
产品描述

A potent, selective 5-HT2A inverse agonist with pKi of 9.2; displays >30- and 5000-fold selectivity compared with 5-HT2C and 5-HT2B receptors; prevents DOI-induced hypolocomotion and increases sleep consolidation; orally active.Depression Phase 2 Discontinued
同义词

APD-125;RVT-102
通路

Endocrinology/Hormones
靶点

5-HT Receptor
受体

5-HT Receptor
研究领域

Neurological Disease
适应症

Depression

CAS Number

839713-36-9
分子量

437.24
分子式

C18H15BrF2N4O2
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 32 mg/mL
SMILES

O=C(NC1=CC=C(F)C=C1F)NC2=CC=C(OC)C(C3=C(Br)C=NN3C)=C2
化学全称

Urea, N-[3-(4-bromo-1-methyl-1H-pyrazol-5-yl)-4-methoxyphenyl]-N'-(2,4-difluorophenyl)-

1. Teegarden BR, et al. J Med Chem. 2010 Mar 11;53(5):1923-36.
2. Al-Shamma HA, et al. J Pharmacol Exp Ther. 2010 Jan;332(1):281-90.

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