NXL101 ( NXL 101 )

产品货号. M16502 CAS No. 904302-98-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

NXL101
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

NXL101 is a novel quinoline bacterial DNA gyrase and topoisomerase IV inhibitor that shows potent activity against gram-positive bacteria.
产品描述

NXL101 is a novel quinoline bacterial DNA gyrase and topoisomerase IV inhibitor that shows potent activity against gram-positive bacteria, including methicillin- and fluoroquinolone-resistant strains; inhibits S. aureus DNA gyrase and topoisomerase IV with IC50 of 1.0 and 18 uM, respectively.Bacterial Infection Phase 1 Discontinued
同义词

NXL 101
通路

GPCR/G Protein
靶点

Antibacterial
受体

Antibacterial
研究领域

Infection
适应症

Bacterial Infection

CAS Number

904302-98-3
分子量

504.64
分子式

C25H29FN2O4S2
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C([C@H]1CN(CCSC2=CC=CS2)CC[C@H]1CC[C@@H](C3=C(F)C=NC4=CC=C(OC)C=C34)O)O
化学全称

(3R,4R)-4-[(3S)-3-(3-Fluoro-6-methoxy-4-quinolinyl)-3-hydroxypropyl]-1-[2-(2-thienylthio)ethyl]-3-piperidinecarboxylic acid

1. Black MT, et al. Antimicrob Agents Chemother. 2008 Sep;52(9):3339-49.

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