ANT431 ( ANT 431;ANT-431 )

产品货号. M12483 CAS No. 1639972-90-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

ANT431
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

ANT431 is a novel potent metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2.
产品描述

ANT431 is a novel potent metallo-β-lactamase (MBL) inhibitor with IC50 of 290 nM and 195 nM for NDM-1 and VIM-2, shows a comparatively weak inhibitor of VIM-1 and IMP-1 (Ki of 14.6 and 4.15 uM, respectively); potentiate the activity of meropenem (MEM) against a broad range of MBL-producing carbapenem-resistant Enterobacteriaceae (CRE), restore its efficacy against an Escherichia coli NDM-1 strain in a murine thigh infection model.
同义词

ANT 431;ANT-431
通路

GPCR/G Protein
靶点

Antibacterial
受体

Antibacterial
研究领域

——
适应症

——

1. Everett M, et al. Antimicrob Agents Chemother. 2018 Mar 12. pii: AAC.00074-18.

计算器

产品手册

关联产品

Polymyxin B nonapept...

Polymyxin B nonapeptide, a cationic cyclic peptide derived by enzymatic processing from the naturally occurring peptide polymyxin B, is able to increase the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics probably by binding to the bacterial lipopolysaccharide (LPS)
FtsZ inhibitor C109

FtsZ inhibitor C109 (Compound 10126109) is a broad spectrum antibacterial compound that inhibits the cell division protein FtsZ, inhibits the FtsZ GTPase activity with IC50 of 8.2 uM.
Tylvalosin tartrate

Tylvalosin tartrate is a macrolide antibiotic that can against Gram-positive bacteria.